Bone Abstracts

Introduction: Cartilage intermediate layer protein (CILP) is a promising marker of osteoarthritis (OA). CILP is an extracellular matrix glycoprotein, which is produced by cartilage chondrocytes. Still, there are data that CILP could be found also in other tissues. We aimed to investigate the expression level of CILP mRNA in the synovial membrane and evaluated the associations of CILP expression with traits of radiographic knee OA (rKOA) and features of histol...

Biomarkers are required to detect early OA for intervention and to monitor disease progression. A collagen type II neoepitope C2C was developed for these purposes. The aims of the study to test: i) the biomarker’s ability to differentiate osteo-arthritis (OA) patients with and without structural changes and ii) possible contribution of progression of the OA.Material and methods: We investigated 159 knee OA patients aged 36–62 (mean 50) years. F...